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Topologically-associating domains: gene warehouses adapted to serve transcriptional regulation.

Authors
  • Razin, Sergey V1, 2, 3
  • Gavrilov, Alexey A1
  • Vassetzky, Yegor S2, 3, 4
  • Ulianov, Sergey V1, 2
  • 1 a Institute of Gene Biology, RAS , Moscow , Russia.
  • 2 b Biological Faculty, Lomonosov Moscow State University , Moscow , Russia.
  • 3 c LIA1066 "Laboratoire Franco-Russe de Recherche en Oncologie," Villejuif, France - Moscow , Russia. , (France)
  • 4 d UMR8126, Université Paris-Sud, Institut de Cancérologie Gustave Roussy , Villejuif , France. , (France)
Type
Published Article
Journal
Transcription
Publication Date
May 26, 2016
Volume
7
Issue
3
Pages
84–90
Identifiers
DOI: 10.1080/21541264.2016.1181489
PMID: 27111547
Source
Medline
Keywords
License
Unknown

Abstract

Structural-functional domains have long been hypothesized to occur in eukaryotic chromosomes, but their existence still remains controversial. Here, we discuss the current state of studies of 3D genome folding and the relation of this folding to the functional organization of the genome.

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