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Topographic distribution of lymph node metastasis in patients with stage IB1 cervical cancer: an analysis of 8314 lymph nodes

Authors
  • Cai, Jing1
  • He, Xiaoqi1
  • Wang, Hongbo1
  • Dong, Weihong1
  • Zhang, Yuan1
  • Zhao, Jing1
  • Willborn, Kay C.2
  • Huang, Bangxing3
  • Wang, Zehua1
  • Jiang, Ping2
  • 1 Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China , Wuhan (China)
  • 2 Carl von Ossietzky University Oldenburg, Georgstrasse 12, Oldenburg, 26121, Germany , Oldenburg (Germany)
  • 3 Huazhong University of Science and Technology, Wuhan, 430022, China , Wuhan (China)
Type
Published Article
Journal
Radiation Oncology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Mar 20, 2021
Volume
16
Issue
1
Identifiers
DOI: 10.1186/s13014-021-01781-x
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundSystematic pelvic lymphadenectomy or whole pelvic irradiation is recommended for the patients with stage IB1 cervical cancer. However, the precise pattern of lymphatic tumor spread in cervical cancer is unknown. In the present study we evaluated the distribution of nodal metastases in stage IB1 cervical cancer to explore the possibilities for tailoring cancer treatment.MethodsA total of 289 patients with cervical cancer of stage IB1, according to FIGO 2009, were retrospectively analyzed. All patients underwent laparoscopic radical hysterectomy (Querleu and Morrow type C2) and systematic pelvic lymphadenectomy with or without para-aortic lymphadenectomy (level 2 or level 3 according to Querleu and Morrow) from October 2014 to December 2017. Lymph nodes removed from 7 well-defined anatomical locations as well as other tissues were examined histopathologically, and typed, graded, and staged according to the WHO/IARC classification.ResultsTotally 8314 lymph nodes were analyzed with the average number of 31.88 ± 10.34 (Mean ± SD) lymph nodes per patient. Nodal metastases were present in 44 patients (15.22%). The incidence of lymphatic spread to different anatomic sites ranged from 0% (presacral) to 30.92% (obturator nodes). Tumor size above 2 cm, histologically proven lymphovascular space involvement (LVSI) and parametrial invasion were shown to be significantly correlated with the higher risk of lymphatic metastasis, while obesity (BMI ≥ 25) was independently negatively associated with lymphatic metastases.ConclusionsThe incidence of lymph node metastasis in patients with stage IB1 cervical cancer is low but prognostically relevant. Individual treatment could be considered for the selected low-risk patients who have smaller tumors and obesity and lack of the parametrial invasion or LVSI.

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