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Topiramate as a neuroprotectant in the experimental model of febrile seizures.

Authors
  • Sendrowski, K
  • Sobaniec, W
  • Sobaniec-Lotowska, M E
  • Artemowicz, B
Type
Published Article
Journal
Advances in medical sciences
Publication Date
Jan 01, 2007
Volume
52 Suppl 1
Pages
161–165
Identifiers
PMID: 18229656
Source
Medline
License
Unknown

Abstract

Our findings seem to confirm that FS exert a strong destructive effect on the sensitive hippocampal neurons and on the neuroprotective properties of TPM in this process, which may have practical implications. It can be assumed that in children with recurrent and prolonged FS, prophylactic drug administration could prevent hippocampal sclerosis and development of symptomatic epilepsy.

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