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Topical sirolimus for treatment of a venolymphatic malformation in an adolescent girl.

Authors
  • Cardis, Michael A1
  • DeKlotz, Cynthia M C1
  • 1 MedStar Washington Hospital Center/MedStar Georgetown University Hospital, Washington, District of Columbia.
Type
Published Article
Journal
Pediatric Dermatology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Nov 01, 2018
Volume
35
Issue
6
Identifiers
DOI: 10.1111/pde.13622
PMID: 30152558
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Sirolimus has emerged as a promising treatment for complex congenital vascular malformations but is limited because of systemic side effects. Topically compounded formulations, which have been found to be successful in the treatment of several other conditions, are a preferred drug delivery system to provide local therapy. We report a case of a venolymphatic malformation in an adolescent girl treated with topical 1% sirolimus cream leading to improvement in appearance and associated symptoms. © 2018 Wiley Periodicals, Inc.

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