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Topical Application of Naltrexone to the Ocular Surface of Healthy Volunteers: A Tolerability Study.

Authors
  • Liang, David1
  • Sassani, Joseph W1
  • McLaughlin, Patricia J2
  • Zagon, Ian S2
  • 1 1 Department of Ophthalmology, Pennsylvania State University College of Medicine , Hershey, Pennsylvania.
  • 2 2 Department of Neural & Behavioral Sciences, Pennsylvania State University College of Medicine , Hershey, Pennsylvania.
Type
Published Article
Journal
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
Publication Date
March 2016
Volume
32
Issue
2
Pages
127–132
Identifiers
DOI: 10.1089/jop.2015.0070
PMID: 26741052
Source
Medline
License
Unknown

Abstract

Topical naltrexone was well tolerated in healthy human subjects after 1 or 4 eye drops of naltrexone at dosages up to 50 μM administered over a 24-h treatment period and observed for 1 week.

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