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Topical antiinflammatory activity of the major lipophilic constituents of the rhizome of Zingiber cassumunar. Part II: Hexane extractives.

Authors
  • Pongprayoon, U
  • Tuchinda, P
  • Claeson, P
  • Sematong, T
  • Reutrakul, V
  • Soontornsaratune, P
Type
Published Article
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Publication Date
Feb 01, 1997
Volume
3
Issue
4
Pages
323–326
Identifiers
DOI: 10.1016/S0944-7113(97)80004-9
PMID: 23195189
Source
Medline
License
Unknown

Abstract

A hexane extract of the rhizome of Zingiber cassumunar was found to exhibit topical antiinflammatory activity, when tested in the model of 12-O-tetradecanoylphorbol-13-acetate-induced ear edema in rats (ID(50) = 854 μg/ear). Bioassay-guided fractionation (by MPLC on silica gel) of the hexane extract led to the isolation and identification of (E)-4-(3',4'-dimethoxyphenyl)but-3-enyl acetate (1), cis-3-(3',4'-dimethoxyphenyl)-4-[(E)-3,‴,4‴- dimethoxystyryl]cyclohex-l-ene (2), cis-3-(3',4'-dimethoxyphenyl)-4-[(E)-2‴,4‴,5‴- trimethoxystyryl]cyclohex-1-ene (3), cis-3-(2',4',5'-trimethoxyphenyl)-4-[(E)-2‴,4‴,5‴- trimethoxystyryl]cyclohex-l-ene (4) and (E)-4-(3'-4'-dime-thoxyphenyl)but-3-en-l-ol (5). Compounds 1-5 exerted potent topical antiinflammatory activities with ID(50)-values of 62, 21, 20, 2 and 47μg/ear, respectively. The ID(50) of the reference drug diclofenac was determined to be 61 μg/ear.

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