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Tongsaimai reverses the hypertension and left ventricular remolding caused by abdominal aortic constriction in rats.

Authors
  • Meng, Qinghai1
  • Guo, Yao2
  • Zhang, Dini3
  • Zhang, Qichun4
  • Li, Yu5
  • Bian, Huimin6
  • 1 School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, China. Electronic address: [email protected] , (China)
  • 2 Nanjing TechBoon Biotechnology Company Limited, Nanjing, Jiangsu, 211899, China. Electronic address: [email protected] , (China)
  • 3 Department of Environmental Protection, Nanjing Institute of Environmental Sciences, Nanjing, Jiangsu, 210042, China. Electronic address: [email protected] , (China)
  • 4 School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, China. Electronic address: [email protected] , (China)
  • 5 School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, China. Electronic address: [email protected] , (China)
  • 6 School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Journal of ethnopharmacology
Publication Date
Jan 10, 2020
Volume
246
Pages
112154–112154
Identifiers
DOI: 10.1016/j.jep.2019.112154
PMID: 31415848
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Treating ventricular remodeling continues to be a clinical challenge. Studies have shown that hypertension is one of the most common causes of ventricular remodeling, and is a major cause of cardiovascular risk in adults. Here, we report that Tongsaimai (TSM), a Chinese traditional medicine, could inhibit arterial pressure and left ventricular pressure to improve hemodynamic abnormalities in rats impaired by abdominal aortic constriction (AAC). Administration of TSM significantly reduced the heart mass index and the left ventricular mass index significantly in AAC rats. TSM could also markedly ameliorate cardiac collagen deposition and reduce the concentration of hydroxyproline in the heart of AAC rats. Moreover, TSM alleviated cardiac histomorphology injury resulting from AAC, including reducing cardiomyocyte hypertrophy, fibrous connective tissue hyperplasia, cardiomyocyte apoptosis, replacement fibrosis and the disorders of myocardial myofibrils, intercalated discs, mitochondria and mitochondrial crista. In addition, the levels of transforming growth factor (TGF) - β and inflammation-related molecules including tumor necrosis factor-α (TNF-α), which were over-expressed with AAC, were decreased by STM. In conclusion, STM could reverse the hypertension and left ventricular remolding caused by abdominal aortic constriction in rats. Copyright © 2019 Elsevier B.V. All rights reserved.

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