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Tollip-induced down-regulation of MARCH1

Authors
  • Bourgeois-Daigneault, Marie-Claude
  • Pezeshki, Abdul Mohammad
  • Galbas, Tristan
  • Houde, Mathieu
  • Baril, Martin
  • Früh, Klaus
  • Amrani, Abdelaziz
  • Ishido, Satoshi
  • Lamarre, Daniel
  • Thibodeau, Jacques1, 2, 3, 4, 5, 6, 7, 8, 9, 10
  • 1 Laboratoire d'Immunologie Moléculaire
  • 2 Département de Microbiologie et Immunologie, Université de Montréal
  • 3 Institut de recherche en immunologie et en cancérologie
  • 4 IRIC, Université de Montréal
  • 5 Vaccine and Gene Therapy Institute
  • 6 Oregon Health and Science University
  • 7 Département de Pédiatrie
  • 8 Service d’Immunologie et d'Allergologie, Université de Sherbrooke
  • 9 Laboratory of Infectious Immunity, Yokohama Institute
  • 10 Research Center for Allergy and Immunology
Type
Published Article
Journal
Results in Immunology
Publication Date
Jan 01, 2013
Accepted Date
Feb 14, 2013
Volume
3
Pages
17–25
Identifiers
DOI: 10.1016/j.rinim.2013.02.002
Source
Elsevier
Keywords
License
Unknown

Abstract

•Splenocytes from MARCH1- and Ii-deficient mice are impaired in cytokine production following TLR stimulation.•MHC class II molecules bind TLR3.•Tollip regulates endocytic trafficking of MHC II proteins and chaperones.•Tollip binds MHC II molecules

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