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Toll-like receptors in wound healing: location, accessibility, and timing.

Authors
Type
Published Article
Journal
Journal of Investigative Dermatology
Publisher
Elsevier
Publication Date
Aug 17, 2012
Volume
132
Issue
8
Pages
1955–1955
Identifiers
DOI: 10.1038/jid.2012.208
PMID: 22797299
Source
Isseroff Lab dermatology-ucdavis
License
Green

Abstract

Toll-like receptors (TLRs) are considered to be the first responders in the defense against invading pathogens. TLR engagement by ligands triggers inflammatory responses in injury and trauma, and thus can impair or contribute to the healing process, depending on TLRs expression pattern, cellular localization, signaling, and deployment of inflammatory responses. Understanding these attributes could improve therapeutic strategies for treating chronic wounds.

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