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Toll-like receptors and graft rejection.

Authors
Type
Published Article
Journal
Transplant immunology
Publication Date
Volume
16
Issue
1
Pages
25–31
Identifiers
PMID: 16701173
Source
Medline
License
Unknown

Abstract

Innate immunity plays a role in fighting against invading microorganisms. Emerging evidence suggests that in addition to responding to pathogen-associated molecular patterns of microorganisms, Toll-like receptors (TLRs) can be activated by endogenous ligands expressed by mammalian cells. Clinical and laboratory studies have shown that TLRs may participate in organ graft rejection and transplant immune tolerance, which are briefly reviewed in the present manuscript.

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