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Toll-like receptor expression pattern: clinical application.

Authors
Type
Published Article
Journal
Journal of Clinical Immunology
1573-2592
Publisher
Springer-Verlag
Publication Date
Volume
32
Issue
6
Pages
1421–1422
Identifiers
DOI: 10.1007/s10875-012-9719-7
PMID: 22711010
Source
Medline
License
Unknown

Abstract

We read with interest the recent paper in the JoCI, entitled 'Study of the expression of Toll-Like Receptors in Different Histological Types of Colorectal Polyps and Their Relationship with Colorectal Cancer' by Eiró et al. TLR7 and 9 expression is altered in CRC vs. normal control; which is proposed to be correlated with adenomacarcinoma progression. The fact that other TLRs were not observed to be differentially expressed is in contrast with published reports; which could be explained by the limitations of the employed method and disregarding the spatiotemporal variation in TLR expression pattern.

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