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Toll-like receptor and antiphospholipid mediated thrombosis: in vivo studies.

Authors
  • Pierangeli, Silvia S
  • Vega-Ostertag, Mariano E
  • Raschi, Elena
  • Liu, Xiaowei
  • Romay-Penabad, Zurina
  • De Micheli, Valeria
  • Galli, Monica
  • Moia, Marco
  • Tincani, Angela
  • Borghi, Maria Orietta
  • Nguyen-Oghalai, Tracy
  • Meroni, Pier Luigi
Type
Published Article
Journal
Annals of the rheumatic diseases
Publication Date
Oct 01, 2007
Volume
66
Issue
10
Pages
1327–1333
Identifiers
PMID: 17261530
Source
Medline
License
Unknown

Abstract

These findings in LPS-/- mice and the reduction in the "protective" polymorphism in patients with APS with thrombosis suggest that TLR-4 is involved in the interaction of aPL with endothelial cells in vivo.

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