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Toll-like receptor 2-mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors.

Authors
Type
Published Article
Journal
Hepatology
1527-3350
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
55
Issue
1
Pages
287–297
Identifiers
DOI: 10.1002/hep.24625
PMID: 21898480
Source
Medline
License
Unknown

Abstract

Using primary human liver cells, we identified a novel mechanism of rAAV recognition in the liver, demonstrating that alternative means of sensing rAAV particles have evolved. Minimizing this recognition will be key to improving rAAV-mediated gene transfer and reducing side effects in clinical trials due to immune responses against rAAV.

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