Effectiveness of tocolytic strategies are difficult to prove and should called in question. Tocolysis by betaadrenergic agents inhibit a symptom without eliminating causing pathologies. Initial steps in etiology as well as therapy should be based on the entire organism including the psyche with a special focus on uterus, cervix and feto-placental unit. Magnesium depletion and infection are important causes of preterm labour. Application of betaadrenergic agonists should be pulsatile by bolus tocolysis demonstrating rare side effects.