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Toborinone and olprinone, phosphodiesterase III inhibitors, inhibit human platelet aggregation due to the inhibition of both calcium release from intracellular stores and calcium entry.

Authors
  • Kageyama, Kyoko
  • Mizobe, Toshiki
  • Nozuchi, Shinji
  • Hiramatsu, Noriko
  • Nakajima, Yasufumi
  • Aoki, Hiroshi
Type
Published Article
Journal
Journal of anesthesia
Publication Date
Jan 01, 2004
Volume
18
Issue
2
Pages
107–112
Identifiers
PMID: 15127258
Source
Medline
License
Unknown

Abstract

Toborinone (9.7 micro M) and olprinone (3.6 micro M) inhibit human platelet aggregation, though these concentrations are higher than their therapeutic plasma concentrations. The inhibitory effects of both drugs are related to the inhibition of both Ca2+ release and Ca2+ entry through [cAMP]i elevation.

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