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TNF-alpha: mRNA, plasma protein levels and soluble receptors in patients on chronic hemodialysis, on CAPD and with end-stage renal failure.

Authors
  • van Riemsdijk-van Overbeeke, I C
  • Baan, C C
  • Hesse, C J
  • Loonen, E H
  • Niesters, H G
  • Zietse, R
  • Weimar, W
Type
Published Article
Journal
Clinical Nephrology
Publisher
Dustri-Verlag Dr. Karl Feistle
Publication Date
Feb 01, 2000
Volume
53
Issue
2
Pages
115–123
Identifiers
PMID: 10711413
Source
Medline
License
Unknown

Abstract

This suggests that only during chronic HD is the TNF-alpha system activated. High levels of sTNFR, found in ESRF or CAPD patients do not reflect activation of TNF-alpha system, but are the result of impaired renal clearance of the receptors. Indeed, we found a strong linear correlation between the levels of sTNF receptors and renal function. Nevertheless, these high levels of sTNF receptors are biological active, as they were able to bind active TNF-alpha up to 75% (range 46 - 83%) and thus inhibit the bioactivity and bioavailability of produced TNF-alpha. This may play a role in the immunoincompetence of these patients.

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