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TNF-alpha and chronic fatigue syndrome.

Authors
  • Moss, R B
  • Mercandetti, A
  • Vojdani, A
Type
Published Article
Journal
Journal of Clinical Immunology
Publisher
Springer Nature
Publication Date
Sep 01, 1999
Volume
19
Issue
5
Pages
314–316
Identifiers
PMID: 10535608
Source
Medline
License
Unknown

Abstract

Based upon the clinical presentation of chronic fatigue syndrome (CFS), we hypothesized that proinflammatory cytokines may play a role in the pathogenesis of the disease. We therefore undertook a retrospective cross-sectional study to examine the role of TNF-alpha in patients with CFS. Our results suggest a significant increase serum TNF-alpha in patients with CFS (P<0.0001) compared to non-CFS controls. This study supports the further examination of the role of proinflammatory mediators in CFS. Furthermore, the clinical testing of TNF-alpha blockers and other antiinflammatory agents for the treatment of this disease is warranted.

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