TMC function in hair cell transduction
- Authors
- Type
- Published Article
- Journal
- Hearing Research
- Publisher
- Elsevier BV
- Publication Date
- Jan 01, 2014
- Accepted Date
- Jan 02, 2014
- Identifiers
- DOI: 10.1016/j.heares.2014.01.001
- Source
- Elsevier
- License
- Unknown
Abstract
•Over 30 TMC1 mutations have been identified that cause deafness in mice and humans.•Eight mammalian TMC genes have been identified and a few are found in invertebrates.•Hair cells express Tmc1 and Tmc2 and the proteins can be found at stereocilia tips.•Hair cells that express TMC1 or TMC2 have distinct biophysical properties.•Hair cells that express mutant TMC1 have reduced calcium selectivity.
