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TMC function in hair cell transduction

Authors
  • Holt, Jeffrey R.
  • Pan, Bifeng
  • Koussa, Mounir A.
  • Asai, Yukako1, 2, 3, 4, 5, 6, 4
  • 1 Department of Otolaryngology
  • 2 F.M. Kirby Neurobiology Center
  • 3 Boston Children's Hospital
  • 4 Harvard Medical School
  • 5 Program in Neuroscience
  • 6 Department of Neurobiology
Type
Published Article
Journal
Hearing Research
Publisher
Elsevier BV
Publication Date
Jan 01, 2014
Accepted Date
Jan 02, 2014
Identifiers
DOI: 10.1016/j.heares.2014.01.001
Source
Elsevier
License
Unknown

Abstract

•Over 30 TMC1 mutations have been identified that cause deafness in mice and humans.•Eight mammalian TMC genes have been identified and a few are found in invertebrates.•Hair cells express Tmc1 and Tmc2 and the proteins can be found at stereocilia tips.•Hair cells that express TMC1 or TMC2 have distinct biophysical properties.•Hair cells that express mutant TMC1 have reduced calcium selectivity.

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