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TLR3 regulates mycobacterial RNA-induced IL-10 production through the PI3K/AKT signaling pathway

Authors
  • Bai, Wenjuan
  • Liu, Haipeng
  • Ji, Qun
  • Zhou, Yilong
  • Liang, Le
  • Zheng, Ruijuan
  • Chen, Jianxia
  • Liu, Zhonghua
  • Yang, Hong
  • Zhang, Peng
  • Kaufmann, Stefan H.E.
  • Ge, Baoxue1, 2, 3, 4, 3, 5, 2, 3, 6, 7
  • 1 Shanghai TB Key Laboratory
  • 2 Shanghai Pulmonary Hospital
  • 3 Tongji University School of Medicine
  • 4 Department of Microbiology and Immunology
  • 5 Clinical Translational Research Center
  • 6 Department of Immunology
  • 7 Max Planck Institute for Infection Biology
Type
Published Article
Journal
Cellular Signalling
Publisher
Elsevier
Publication Date
Jan 01, 2014
Accepted Date
Jan 16, 2014
Volume
26
Issue
5
Pages
942–950
Identifiers
DOI: 10.1016/j.cellsig.2014.01.015
Source
Elsevier
Keywords
License
Unknown

Abstract

•Fine-tuning of IL-10 production in the host is essential for TB control.•TLR3 deficiency protects mice from BCG infection.•TLR3-PI3K/AKT mediates BCG-induced IL-10 production in macrophages.•Sensing of mycobacterial RNA by TLR3 is responsible for IL-10 induction.•TLR3 is identified as a novel PRR in mycobacterial diseases such as TB or leprosy.

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