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Doxorubicin-Conjugated Iron Oxide Nanoparticles Synthesized by Laser Pyrolysis: In Vitro Study on Human Breast Cancer Cells.

Authors
  • Lungu, Iulia Ioana1, 2
  • Nistorescu, Simona1, 3
  • Badea, Mădălina Andreea3
  • Petre, Andreea-Mihaela3
  • Udrea, Ana-Maria1, 3
  • Banici, Ana-Maria1
  • Fleacă, Claudiu1
  • Andronescu, Ecaterina2
  • Dinischiotu, Anca3
  • Dumitrache, Florian1
  • Staicu, Angela1
  • Balaș, Mihaela3
  • 1 National Institute of Laser, Plasma and Radiation Physics, 409 Atomistilor Street, 077125 Magurele, Ilfov, Romania. , (Oman)
  • 2 Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Gh. Polizu Street, 011061 Bucharest, Romania. , (Oman)
  • 3 Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania. , (Oman)
Type
Published Article
Journal
Polymers
Publisher
MDPI AG
Publication Date
Nov 26, 2020
Volume
12
Issue
12
Identifiers
DOI: 10.3390/polym12122799
PMID: 33256060
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Even today, breast cancer remains a global public problem, with a high mortality rate among women. Nanoparticle (NP) based systems are developed to enhance drug delivery, reducing the toxic effect of medicine molecules. By using iron oxide nanoparticles for cancer treatment, several advantages were highlighted: the ability to target specific locations derived from their magnetic properties and reduced side effects. The aim of this study was to examine on breast cancer cell line the anticancer potential of γ-Fe2O3 NPs loaded with doxorubicin (DOX) and stabilized with carboxymethylcellulose sodium (CMCNa). The γ-Fe2O3 NPs were synthesized by laser pyrolysis technique and their nanometric size and crystallinity were confirmed by X-ray diffraction and transmission electron microscopy. The loading efficiency was estimated by using absorption and fluorescence spectroscopy. The DOX conjugated//CMCNa coated γ-Fe2O3 NPs proved through the biological studies to have a good anticancer effect through the inhibition of tumoral cell proliferation, disruption of the cellular membrane, induction of cell death and reduced effects on normal breast cells. Our data showed that DOX cytotoxicity increases significantly when conjugated with ɣ-Fe2O3 and ɣ-Fe2O3_CMCNa, a 50% reduction of cancer cell viability was obtained with a concentration around 0.1 µg/mL.

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