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A progesterone biosensor derived from microbial screening

Authors
  • Grazon, Chloé1, 2
  • Baer, R C.3, 3
  • Kuzmanović, Uroš1
  • Nguyen, Thuy1
  • Chen, Mingfu1
  • Zamani, Marjon1
  • Chern, Margaret1
  • Aquino, Patricia1
  • Zhang, Xiaoman1
  • Lecommandoux, Sébastien2
  • Fan, Andy1
  • Cabodi, Mario1
  • Klapperich, Catherine1, 1
  • Grinstaff, Mark W.1, 1, 1
  • Dennis, Allison M.1, 1
  • Galagan, James E.3, 3, 1
  • 1 Boston University, Boston, MA, 02215, USA , Boston (United States)
  • 2 University Bordeaux, CNRS, Bordeaux INP, LCPO, UMR 5629, Pessac, F-33600, France , Pessac (France)
  • 3 Boston University, Boston, MA, 02118, USA , Boston (United States)
Type
Published Article
Journal
Nature Communications
Publisher
Springer Nature
Publication Date
Mar 09, 2020
Volume
11
Issue
1
Identifiers
DOI: 10.1038/s41467-020-14942-5
Source
Springer Nature
License
Green

Abstract

Bacteria represent an unexploited reservoir of biosensing proteins. Here the authors use genomic screens and functional assays to isolate a progesterone sensing allosteric transcription factor and use a FRET-based method to develop an optical progesterone sensor.

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