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Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses

Authors
  • Behr, Felix M.1, 1
  • Parga-Vidal, Loreto1
  • Kragten, Natasja A. M.1
  • van Dam, Teunis J. P.1, 1
  • Wesselink, Thomas H.1
  • Sheridan, Brian S.2
  • Arens, Ramon3
  • van Lier, Rene A. W.1
  • Stark, Regina1, 1
  • van Gisbergen, Klaas P. J. M.1, 1
  • 1 University of Amsterdam, Amsterdam, the Netherlands , Amsterdam (Netherlands)
  • 2 Stony Brook University, Stony Brook, NY, USA , Stony Brook (United States)
  • 3 Leiden University Medical Center, Leiden, the Netherlands , Leiden (Netherlands)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Jul 13, 2020
Volume
21
Issue
9
Pages
1070–1081
Identifiers
DOI: 10.1038/s41590-020-0723-4
Source
Springer Nature
License
Yellow

Abstract

Van Gisbergen and colleagues show that tissue-resident memory T cells, genetically marked in Hobit reporter mice, can exit tissues upon reinfection and contribute to systemic memory responses.

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