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Tissue source dictates lineage outcome of human fetal CD34(+)CD38(-) cells.

Authors
  • Poznansky, M C1
  • Olszak, I T
  • Foxall, R B
  • Piascik, A
  • Adams, G B
  • Evans, R H
  • Cheng, T
  • Scadden, D T
  • 1 AIDS Research Center and MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Mass., USA.
Type
Published Article
Journal
Experimental Hematology
Publisher
Elsevier
Publication Date
June 2001
Volume
29
Issue
6
Pages
766–774
Identifiers
PMID: 11378272
Source
Medline
License
Unknown

Abstract

Translocation of primitive cells from fetal liver to tissues of mature hematopoietic activity is associated with tissue-specific, quantitative changes in differentiation potential that are unresponsive to alternative differentiation environments. These data suggest that multipotentiality is lost prior to or upon stem-cell migration in the developing human. It is not persistent with residence in a secondary hematopoietic organ.

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