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Tissue source dictates lineage outcome of human fetal CD34(+)CD38(-) cells.

Authors
  • 1
  • 1 AIDS Research Center and MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Mass., USA.
Type
Published Article
Journal
Experimental Hematology
0301-472X
Publisher
Elsevier
Publication Date
Volume
29
Issue
6
Pages
766–774
Identifiers
PMID: 11378272
Source
Medline
License
Unknown

Abstract

Translocation of primitive cells from fetal liver to tissues of mature hematopoietic activity is associated with tissue-specific, quantitative changes in differentiation potential that are unresponsive to alternative differentiation environments. These data suggest that multipotentiality is lost prior to or upon stem-cell migration in the developing human. It is not persistent with residence in a secondary hematopoietic organ.

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