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Tissue factor–dependent thrombin generation across pregnancy

Authors
  • McLean, Kelley C.
  • Bernstein, Ira M.
  • Brummel-Ziedins, Kathleen E.
Type
Published Article
Journal
American Journal of Obstetrics and Gynecology
Publisher
Elsevier
Publication Date
Jan 01, 2012
Accepted Date
May 30, 2012
Volume
207
Issue
2
Pages
135–135
Identifiers
DOI: 10.1016/j.ajog.2012.05.027
Source
Elsevier
Keywords
License
Unknown

Abstract

ObjectiveNormal pregnancy results in a prothrombotic state. Studies that have investigated the capacity of pregnant women to generate thrombin are limited. Our aim was to evaluate thrombin generation longitudinally from the preconception period, through pregnancy, and after pregnancy. Study DesignWe evaluated young, healthy nulligravid women (n = 20) at 4 time points and compared the data with 10 control women at 2 time points. Coagulation was initiated with tissue factor in contact pathway inhibited plasma, and thrombin generation was determined in the presence of a fluorogenic substrate. ResultsThe maximum level and rate of thrombin generation increased during pregnancy; the highest level and rate occurred in late pregnancy compared with prepregnancy (P < .001). Subsequently, thrombin generation decreased in the postpregnancy samples that included maximum level, rate, and area under the curve (P < .001). ConclusionOur data provide evidence for an increase in tissue factor–dependent thrombin generation with pregnancy progression, followed by a return to prepregnancy thrombin levels.

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