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[Tissue factor molecules and some other indices of coagulation hemostasis in patients with rheumatic heart disease].

Authors
Type
Published Article
Journal
Klinicheskaia meditsina
Publication Date
Volume
86
Issue
8
Pages
47–50
Identifiers
PMID: 18819347
Source
Medline
License
Unknown

Abstract

This comparative study of interleukins, tissue factor activity, and certain parameters of coagulation hemostasis included patients with rheumatic heart disease. It revealed an increased production of proinflammatory cytokines including interleukin-1b (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) in all groups of patients. The procoagulative activity was also enhanced and positively correlated with the IL-1 beta level. Tissue factor activity was directly proportional to the concentration of IL-1 beta and inversely proportional to that of interleukin-4 (IL-4).

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