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Tissue factor activity in women with preeclampsia or SGA: a potential explanation for the excessive thrombin generation in these syndromes.

Authors
  • Erez, Offer1, 2
  • Romero, Roberto1, 3, 4, 5
  • Vaisbuch, Edi1, 2
  • Than, Nandor Gabor1, 2, 6, 7, 8
  • Kusanovic, Juan Pedro1, 9, 10
  • Mazaki-Tovi, Shali1, 2
  • Gotsch, Francesca1, 11
  • Mittal, Pooja1, 2
  • Dong, Zhong1, 2
  • Chaiworapongsa, Tinnakorn1, 2
  • Kim, Chong Jai1, 12
  • Nhan-Chang, Chia-Ling1, 2, 13
  • Kim, Sun Kwon1, 2
  • Yeo, Lami1, 2
  • Mazor, Moshe14
  • Hassan, Sonia S1, 2
  • 1 a Perinatology Research Branch , NICHD/NIH/DHHS , Bethesda , MD, and Detroit, MI , USA.
  • 2 b Department of Obstetrics and Gynecology , Wayne State University School of Medicine , Detroit , MI , USA.
  • 3 c Department of Obstetrics and Gynecology , University of Michigan , Ann Arbor , MI , USA.
  • 4 d Department of Epidemiology and Biostatistics , Michigan State University , East Lansing , MI , USA.
  • 5 e Center for Molecular Medicine and Genetics , Wayne State University , Detroit , MI , USA.
  • 6 f Maternity Private Department, Kutvolgyi Clinical Block , Semmelweis University , Budapest , Hungary. , (Hungary)
  • 7 g Systems Biology of Reproduction Lendulet Research Group , Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences , Budapest , Hungary. , (Hungary)
  • 8 h First Department of Pathology and Experimental Cancer Research , Semmelweis University , Budapest , Hungary. , (Hungary)
  • 9 i Department of Obstetrics and Gynecology, Center for Research and Innovation in Maternal-Fetal Medicine (CIMAF) , Sótero del Río Hospital , Santiago , Chile. , (Chile)
  • 10 j Division of Obstetrics and Gynecology, Faculty of Medicine , Pontificia Universidad Católica de Chile , Santiago , Chile. , (Chile)
  • 11 k Department of Obstetrics and Gynecology, Azienda , Ospedaliera Universitaria Integrata , Verona , Italy. , (Italy)
  • 12 l Department of Pathology , University of Ulsan College of Medicine , Seoul , Republic of Korea. , (North Korea)
  • 13 m Department of Obstetrics and Gynecology , Columbia University , New York , NY , USA.
  • 14 n Department of Obstetrics and Gynecology , Ben-Gurion University , Beer-Sheva , Israel. , (Israel)
Type
Published Article
Journal
The Journal of Maternal-Fetal & Neonatal Medicine
Publisher
Informa UK (Taylor & Francis)
Publication Date
Jun 01, 2018
Volume
31
Issue
12
Pages
1568–1577
Identifiers
DOI: 10.1080/14767058.2017.1320543
PMID: 28521572
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The aim of this study was to determine whether the activity of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in the plasma of women with preeclampsia (PE) and small for gestational age (SGA) neonate differ from that of normal pregnant women and whether they are related to specific placental lesions. This cross-sectional study included the following groups: (1) normal pregnancy (n = 68); (2) PE (n= 128); and (3) SGA (n = 56). Maternal plasma TF and TFPI activity was determined with chromogenic assays. (1) The median maternal plasma TF activity, but not TFPI activity, differed among the study groups (p < .0001 and p = .4, respectively); (2) patients with PE had a higher median maternal plasma TF activity than women with normal pregnancies (p < .0001) and mothers with SGA fetuses (p = .002); (3) among patients with PE, those with distal villous hypoplasia had a higher median maternal TF activity than those without these placental lesions (p = .018); and (4) following adjustment for confounding variables, maternal plasma TF and TFPI activity were not associated with an SGA neonate. Plasma TF activity is higher in women with PE than in those with SGA or normal pregnancies. We propose that these changes may be responsible, at least in part, for the increased in-vivo thrombin generation observed in this obstetrical syndrome.

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