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Tissue elasticity estimation with optical coherence elastography: toward mechanical characterization of in vivo soft tissue.

Authors
  • Khalil, Ahmad S1
  • Chan, Raymond C
  • Chau, Alexandra H
  • Bouma, Brett E
  • Mofrad, Mohammad R Kaazempur
  • 1 Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Type
Published Article
Journal
Annals of biomedical engineering
Publication Date
Nov 01, 2005
Volume
33
Issue
11
Pages
1631–1639
Identifiers
PMID: 16341928
Source
Medline
License
Unknown

Abstract

High-resolution imaging provides a significant means for accurate material modulus estimation and mechanical characterization. Within the realm of in vivo soft tissue characterization, particularly on small biological length scales such as arterial atherosclerotic plaques, optical coherence tomography (OCT) offers a desirable imaging modality with higher spatial resolution and contrast of tissue as compared with intravascular ultrasound (IVUS). Based on recent advances in OCT imaging and elastography, we present a fully integrated system for tissue elasticity reconstruction, and assess the benefits of OCT on the distribution results of four representative tissue block models. We demonstrate accuracy, with displacement residuals on the order of 10(-6) mm (more than 3 orders of magnitude less than average calculated displacements), and high-resolution estimates, with the ability to resolve inclusions of 0.15 mm diameter.

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