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Tissue deposition and metabolism of 125I-labeled synthetic amino-terminal parathyroid hormone bPTH(1-34).

Authors
  • Schneider, N
  • Teitelbaum, A P
  • Neuman, W F
Type
Published Article
Journal
Calcified tissue international
Publication Date
Jan 01, 1980
Volume
30
Issue
2
Pages
147–150
Identifiers
PMID: 6769562
Source
Medline
License
Unknown

Abstract

The tissue deposition and metabolism of 125I-labeled synthetic amino-terminal parathyroid hormone, bPTH(1-34), were studied in rats. In comparison with the intact hormone molecule bPTH(1-84), the synthetic fragment was (a) cleared more rapidly from serum; (b) degraded more rapidly in peripheral tissues; (c) deposited to a greater extent in kidney; (d) deposited to a much smaller extent in liver. In bone, the accumulation of total radioactivity was approximately the same with both labeled hormones. The possible physiological significance of these patterns of distribution and metabolism is discussed.

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