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Timolol concentrations in breast milk of a woman treated for glaucoma: calculation of neonatal exposure.

Authors
  • Madadi, Parvaz
  • Koren, Gideon
  • Freeman, David J
  • Oertel, Reinhard
  • Campbell, Robert J
  • Trope, Graham E
Type
Published Article
Journal
Journal of glaucoma
Publication Date
Jan 01, 2008
Volume
17
Issue
4
Pages
329–331
Identifiers
DOI: 10.1097/IJG.0b013e31815c3a5b
PMID: 18552619
Source
Medline
License
Unknown

Abstract

A 32-year-old lactating woman with open-angle glaucoma used timolol maleate 0.5% eye drops twice daily to her right eye for 6 months. Four milk samples were collected over a span of 6 days. Timolol maleate milk levels were examined by liquid chromatography tandem mass spectrometry and found to be at a mean of 0.12 ng/mL (range, 0 to 0.37 ng/mL). At this level, the theoretical maximum relative infant dose expressed as a percentage of the weight-adjusted maternal dose was 0.012%. As most glaucoma patients administer drops to both eyes, the dosage was duplicated to reflect the more pertinent calculated theoretical relative infant dose of 0.024%. This dose of timolol is unlikely to cause systemic side effects to the healthy breastfed infant.

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