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[Timely diagnosis of disseminated paracoccidioidomycosis in an immunocompetent adult].

Authors
  • Vázquez, Carolina1
  • Orlova, María2
  • Zarba, Martín2
  • Catanzariti, María J3
  • Christiansen, Silvia B4
  • Dalurzo, Mercedes C L4
  • Freixas, Antonio A2
  • Vallone, Marcelo G2
  • 1 Clínica Médica, Departamento de Medicina Interna, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. E-mail: [email protected] , (Argentina)
  • 2 Clínica Médica, Departamento de Medicina Interna, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. , (Argentina)
  • 3 Micología, Laboratorio Central, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. , (Argentina)
  • 4 Anatomía Patológica, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. , (Argentina)
Type
Published Article
Journal
Medicina
Publication Date
Jan 01, 2018
Volume
78
Issue
3
Pages
199–202
Identifiers
PMID: 29940548
Source
Medline
Keywords
Language
Spanish
License
Unknown

Abstract

Paracoccidioidomycosis is endemic in subtropical rainforests of Latin America. Acute/subacute presentations involve an aggressive dissemination throughout the lymphatic system, while chronic forms (more frequent) arise as differential diagnosis for other conditions involving lung, oropharynx, skin, and eventually the brain. We present the case of a man referred for evaluation and treatment of a possible lung tumor with brain metastasis. The finding of multibudded yeasts and the microbiological isolation of a dimorphic fungus identified as Paracoccidioides sp. from a brain biopsy prompted a cardinal change in prognosis and treatment. This case alerts on the importance of considering systemic fungal diseases as differential diagnosis of compatible clinical presentations in patients who had lived in, or visited, endemic areas.

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