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Timeliness of rotavirus vaccination at sentinel sites in four early-adopter African countries.

Authors
  • Pindyck, Talia1
  • Tate, Jacqueline E2
  • Bonkoungou, Isidore Juste O3
  • Armah, George4
  • Mujuru, Hilda Angela5
  • Rugambwa, Celse6
  • Mwenda, Jason M7
  • Parashar, Umesh2
  • 1 Epidemic Intelligence Services (EIS), Centers for Disease Control and Prevention (CDC), United States; Division of Viral Diseases, CDC, United States. Electronic address: [email protected] , (United States)
  • 2 Division of Viral Diseases, CDC, United States. , (United States)
  • 3 UFR/SVT, University Ouaga 1, Pr Joseph KI-ZERBO, Burkina Faso; National Public Health Laboratory, Ouagadougou, Burkina Faso. , (Burkina Faso)
  • 4 Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Ghana. , (Ghana)
  • 5 Department of Pediatrics and Child Health, University of Zimbabwe, College of Health Sciences, Zimbabwe. , (Zimbabwe)
  • 6 WHO Country Office, Kigali, Rwanda. , (Rwanda)
  • 7 WHO Regional Office for Africa, WHO/AFRO, Brazzaville, Congo. , (Congo - Kinshasa)
Type
Published Article
Journal
Vaccine
Publication Date
Sep 20, 2019
Volume
37
Issue
40
Pages
6002–6007
Identifiers
DOI: 10.1016/j.vaccine.2019.08.008
PMID: 31455587
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The majority of countries with the highest rotavirus-associated death rates are in sub-Saharan Africa. In 2009, the World Health Organization (WHO) recommended routine vaccination against rotavirus worldwide, with unique age recommendations to administer the first dose before 15 weeks of age and last dose by 32 weeks of age. These age restrictions were relaxed in January 2013, but they may still lead to lower rotavirus vaccine coverage. Children age-eligible to have received rotavirus vaccine that were enrolled in Ghana, Zimbabwe, Rwanda or Burkina Faso's active rotavirus surveillance platforms from 2013 to 2017 and had a stool specimen that tested rotavirus-negative were included in the analysis. Proportion vaccinated and timeliness of rotavirus vaccine versus DTPw-HepB-Hib (pentavalent) first dose and last dose were compared at weeks 15 and 32, respectively, using Chi-square analyses. Odds ratios were calculated using logistic regression. Among children who received rotavirus vaccine dose 1, 96-99% received this dose by 15 weeks of age and among children who received the last dose, 98-99% received it by 32 weeks of age. In all four countries, there was no significant difference in the proportion of children who received first dose rotavirus versus pentavalent vaccine by week 15, or last dose rotavirus versus concordant pentavalent vaccine by week 32. Delayed administration of first dose pentavalent vaccine was significantly associated with missing first dose of rotavirus vaccine in 3 of the 4 countries studied, although delays in administration were rare (1-4%). Rotavirus vaccination was timely among sentinel sites in these four early rotavirus vaccine-introducing countries in Africa. Late presentation for vaccination may have resulted in some children with access to care missing first dose of rotavirus vaccine; however, vaccination delays were infrequent and therefore the potential impact of the age restrictions on overall proportion vaccinated was minimal. Published by Elsevier Ltd.

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