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Time-course changes of hormones and cytokines by lipopolysaccharide and its relation with anorexia.

Authors
  • Kim, Yong-Woon
  • Kim, Keon-Ho
  • Ahn, Dong-Kuk
  • Kim, Hee-Sun
  • Kim, Jong-Yeon
  • Lee, Dong Chul
  • Park, So-Young
Type
Published Article
Journal
The journal of physiological sciences : JPS
Publication Date
Jun 01, 2007
Volume
57
Issue
3
Pages
159–165
Identifiers
PMID: 17481364
Source
Medline
License
Unknown

Abstract

We assessed the time course effects of lipopolysaccaride (LPS) on food intake, cytokines, and hormones in rats and evaluated the relation between LPS-induced anorexia and its possible causative factors. Food intake was reduced 2 h after LPS injection (500 microg/kg, intraperitoneally) and remained decreased for 24 h. Plasma TNF-alpha and IL-6 levels increased by LPS administration at 0.5 and 2 h, and at 2 and 4 h, respectively. Plasma leptin and glucose levels were elevated at 8 and 16 h, and insulin levels were elevated at 2, 4, 8, and 16 h in the LPS-injected group, as compared to the counterpart controls. IL-6 levels in the CSF were elevated at 2 and 4 h. Hypothalamic cytokines tended to increase as early as 0.5 h after LPS injection and remained increased until 16 h. LPS-induced anorexia was attenuated in insulin-deficient STZ rats and was abolished by insulin treatment. The hypothalamic expression of NPY, a target of insulin's anorexic effect, was decreased 2 h after LPS administration, and central NPY injection (3 nM) prevented LPS-induced anorexia. In conclusion, cytokines, insulin, and leptin levels evidence different time courses by LPS administration. In LPS-induced anorexia, insulin may constitute a newly found causative factor, whereas leptin appears to be uninvolved in an early period in rats.

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