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Time on androgen deprivation therapy and adaptations to exercise: secondary analysis from a 12-month randomized controlled trial in men with prostate cancer.

  • Taaffe, Dennis R1, 2, 3
  • Buffart, Laurien M1, 4
  • Newton, Robert U1, 2, 5, 6
  • Spry, Nigel1, 7, 8
  • Denham, James9, 10
  • Joseph, David1, 8, 11
  • Lamb, David12
  • Chambers, Suzanne K1, 13, 14, 15
  • Galvão, Daniel A1, 2
  • 1 Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia. , (Australia)
  • 2 School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia. , (Australia)
  • 3 School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, Qld, Australia. , (Australia)
  • 4 Departments of Epidemiology and Biostatistics and Medical Oncology, VU University Medical Centre, Amsterdam, The Netherlands. , (Netherlands)
  • 5 Institute of Human Performance, University of Hong Kong, Hong Kong, Hong Kong. , (Hong Kong SAR China)
  • 6 University of Queensland Centre for Clinical Research, University of Queensland, Brisbane, Qld, Australia. , (Australia)
  • 7 Genesis CancerCare, Joondalup, WA, Australia. , (Australia)
  • 8 Faculty of Medicine, University of Western Australia, Nedlands, WA, Australia. , (Australia)
  • 9 School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia. , (Australia)
  • 10 Newcastle Mater Hospital, Newcastle, NSW, Australia. , (Australia)
  • 11 Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia. , (Australia)
  • 12 University of Otago, Wellington, New Zealand. , (New Zealand)
  • 13 Menzies Health Institute Queensland, Griffith University, Gold Coast, Qld, Australia. , (Australia)
  • 14 Centre for Research in Cancer, Cancer Council Queensland, Brisbane, Qld, Australia. , (Australia)
  • 15 Prostate Cancer Foundation of Australia, Sydney, NSW, Australia. , (Australia)
Published Article
British Journal of Urology
Wiley (Blackwell Publishing)
Publication Date
Sep 05, 2017
DOI: 10.1111/bju.14008
PMID: 28872752


Men with PCa previously treated long-term with ADT respond more favourably to exercise in terms of lower body muscle performance and body composition (lean and fat mass, and ASM) than those with short-term ADT exposure. As a result, men who were formerly on long-term androgen suppression regimens should be especially prescribed exercise medicine interventions to alleviate residual treatment-related adverse effects.

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