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Tilted-CAIPI for highly accelerated distortion-free EPI with point spread function (PSF) encoding.

Authors
  • Dong, Zijing1
  • Wang, Fuyixue2, 3
  • Reese, Timothy G2
  • Manhard, Mary Katherine2
  • Bilgic, Berkin2
  • Wald, Lawrence L2, 3
  • Guo, Hua1
  • Setsompop, Kawin2, 3
  • 1 Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China. , (China)
  • 2 A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts.
  • 3 Harvard-MIT Health Sciences and Technology, MIT, Cambridge, Massachusetts.
Type
Published Article
Journal
Magnetic Resonance in Medicine
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jan 01, 2019
Volume
81
Issue
1
Pages
377–392
Identifiers
DOI: 10.1002/mrm.27413
PMID: 30229562
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To develop a method for fast distortion- and blurring-free imaging. EPI with point-spread-function (PSF) mapping can achieve distortion- and blurring-free imaging at a cost of long acquisition time. In this study, an acquisition/reconstruction technique, termed "tilted-CAIPI," is proposed to achieve >20× acceleration for PSF-EPI. The proposed method systematically optimized the k-space sampling trajectory with B0 -inhomogeneity-informed reconstruction, to exploit the inherent signal correlation in PSF-EPI and take full advantage of coil sensitivity. Susceptibility-induced phase accumulation is regarded as an additional encoding that is estimated by calibration data and integrated into reconstruction. Self-navigated phase correction was developed to correct shot-to-shot phase variation in diffusion imaging. Tilted-CAIPI was implemented at 3T, with incorporation of partial Fourier and simultaneous multislice to achieve further accelerations. T2 -weighted, T2 * -weighted, and diffusion-weighted imaging experiments were conducted to evaluate the proposed method. The ability of tilted-CAIPI to provide highly accelerated imaging without distortion and blurring was demonstrated through in vivo brain experiments, where only 8 shots per simultaneous slice group were required to provide high-quality, high-SNR imaging at 0.8-1 mm resolution. Tilted-CAIPI achieved fast distortion- and blurring-free imaging with high SNR. Whole-brain T2 -weighted, T2 * -weighted, and diffusion imaging can be obtained in just 15-60 s. © 2018 International Society for Magnetic Resonance in Medicine.

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