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Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice.

Authors
  • Miyamoto, Tatsuo
  • Morita, Kazumasa
  • Takemoto, Daisuke
  • Takeuchi, Kosei
  • Kitano, Yuka
  • Miyakawa, Tsuyoshi
  • Nakayama, Kiyomi
  • Okamura, Yasushi
  • Sasaki, Hiroyuki
  • Miyachi, Yoshiki
  • Furuse, Mikio
  • Tsukita, Shoichiro
Type
Published Article
Journal
The Journal of cell biology
Publication Date
May 09, 2005
Volume
169
Issue
3
Pages
527–538
Identifiers
PMID: 15883201
Source
Medline
License
Unknown

Abstract

Tight junction (TJ)-like structures have been reported in Schwann cells, but their molecular composition and physiological function remain elusive. We found that claudin-19, a novel member of the claudin family (TJ adhesion molecules in epithelia), constituted these structures. Claudin-19-deficient mice were generated, and they exhibited behavioral abnormalities that could be attributed to peripheral nervous system deficits. Electrophysiological analyses showed that the claudin-19 deficiency affected the nerve conduction of peripheral myelinated fibers. Interestingly, the overall morphology of Schwann cells lacking claudin-19 expression appeared to be normal not only in the internodal region but also at the node of Ranvier, except that TJs completely disappeared, at least from the outer/inner mesaxons. These findings have indicated that, similar to epithelial cells, Schwann cells also bear claudin-based TJs, and they have also suggested that these TJs are not involved in the polarized morphogenesis but are involved in the electrophysiological "sealing" function of Schwann cells.

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