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Tight junctional structure and permeability of porcine jejunum after enterotoxic Escherichia coli infection.

Authors
  • Egberts, H J
  • de Groot, E C
  • van Dijk, J E
  • Vellenga, L
  • Mouwen, J M
Type
Published Article
Journal
Research in Veterinary Science
Publisher
Elsevier
Publication Date
Jul 01, 1993
Volume
55
Issue
1
Pages
10–14
Identifiers
PMID: 8378602
Source
Medline
License
Unknown

Abstract

Tight junctional structure and macromolecular permeability were tested in four three-week-old piglets, experimentally infected with the enterotoxigenic Escherichia coli (ETEC) strain O149 K91 K88. Histologically, only minor microscopic evidence of inflammation and little or no architectural changes in the jejunal mucosa were observed. A significant decrease in tight junctional strand numbers occurred, without a concomitant decrease in tight junctional depth. The permeability of the porcine jejunal epithelium to horseradish peroxidase did not change after the ETEC infection.

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