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Thyroid hormone metabolism. A comparative evaluation.

Authors
  • Kaptein, E M
  • Hays, M T
  • Ferguson, D C
Type
Published Article
Journal
The Veterinary clinics of North America. Small animal practice
Publication Date
May 01, 1994
Volume
24
Issue
3
Pages
431–466
Identifiers
PMID: 8053105
Source
Medline
License
Unknown

Abstract

Knowledge of thyroid hormone and iodide metabolism is derived from a combination of in vivo and in vitro studies in a variety of mammalian species including cats, dogs, and humans. Each species provides a unique opportunity to investigate various aspects of normal or altered thyroid hormone physiology. Availability of sensitive and specific human TSH assays has allowed detailed studies of the human hypothalamic-pituitary-thyroid axis which have not been possible in cats and dogs to date. Similarities and differences of thyroid hormone metabolism in dogs, cats, and humans provide the basis for a better understanding of normal physiology as well as shedding light on the significance of changes induced by spontaneous or induced thyroidal and nonthyroidal disorders.

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