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[Thymoma and squamous thymic carcinoma diagnosis; experience from the RYTHMIC network].

Authors
  • Chalabreysse, Lara1
  • Dubois, Romain2
  • Hofman, Véronique3
  • Le Naoures, Cécile4
  • Mansuet-Lupo, Audrey5
  • de Montpréville, Vincent Thomas6
  • De Muret, Anne7
  • Parrens, Marie8
  • Piton, Nicolas9
  • Rouquette, Isabelle10
  • Secq, Véronique11
  • Singeorzan, Cristina12
  • Marx, Alexander13
  • Girard, Nicolas14
  • Besse, Benjamin15
  • Molina, Thierry Jo16
  • 1 Département de pathologie, groupement hospitalier est, hospices civils de Lyon, Lyon, France. , (France)
  • 2 Institut de pathologie, CHU de Lille, Lille, France. , (France)
  • 3 Laboratoire de pathologie clinique et expérimentale, FHU OncoAge, Biobank 0033-00025, université Côte d'Azur, hôpital Pasteur, Nice, France. , (France)
  • 4 Département de pathologie, CHU de Rennes, Rennes, France. , (France)
  • 5 Inserm U1138, centre de recherche des Cordeliers, département de pathologie, université de Paris, hôpital universitaire Cochin, AP-HP centre, Paris, France. , (France)
  • 6 Département de pathologie, hôpital Marie-Lannelongue, Le plessis-Robinson, France. , (France)
  • 7 Service d'anatomie pathologique, CHU de Tours, Tours, France. , (France)
  • 8 Inserm U1053, service d'anatomie pathologique, CHU de Bordeaux, université de Bordeaux, Bordeaux, France. , (France)
  • 9 Inserm U1245, service de pathologie, CHU de Rouen, Rouen, France. , (France)
  • 10 Laboratoire d'anatomie pathologique, CHU de Toulouse oncopole, Toulouse, France. , (France)
  • 11 Département de pathologie, AP-HM Marseille, Marseille, France. , (France)
  • 12 Service d'anatomie pathologique, CHU de Besançon, Besançon, France. , (France)
  • 13 Institut de pathologie, université médicale de Mannheim, université de Heidelberg, Mannheim, Allemagne.
  • 14 Institut du thorax Curie Montsouris, institut Curie, Paris, France. , (France)
  • 15 Département de médecine oncologique, institut Gustave-Roussy, Villejuif, France; Paris-Sud-université, Orsay, France. , (France)
  • 16 Inserm U1163, service d'anatomie pathologique, institut imagine, université de Paris, hôpital universitaire Necker-Enfants malades, AP-HP centre, 149, rue de Sèvres, 75015 Paris, France. Electronic address: [email protected]%20aphp.fr. , (France)
Type
Published Article
Journal
Annales de Pathologie
Publisher
Elsevier
Publication Date
Apr 01, 2021
Volume
41
Issue
2
Pages
154–165
Identifiers
DOI: 10.1016/j.annpat.2020.11.002
PMID: 33309329
Source
Medline
Keywords
Language
French
License
Unknown

Abstract

The RYTHMIC network, supported by the French National Cancer Institute is dedicated to the management of patients with thymic epithelial tumors through regional and national multidisciplinary tumor boards. Tumor board decisions are based on the initial pathology diagnoses. However, following clinical inclusion in the network, a central pathology review is organized, implicating a panel of pathologists, for histotype and stage classification, which is different from a classical second opinion from pathologist to pathologist for a difficult case. Thanks to the participation of all French pathologists, more than 1000 cases have been reviewed by the panel. The aim of this review is to share with the French pathology community, the experience of the group. It underlines the importance of macroscopy and surgeon-pathologist involvement to allow a good central review, the main histopathological and immunophenotypical patterns of the most frequent thymomas and thymic carcinoma types, the differential diagnoses, as well as the difficulties for the panel to reproducibly assess on slides, stage, for some cases. Copyright © 2020 Elsevier Masson SAS. All rights reserved.

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