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Thymoma-associated multiorgan autoimmunity: a graft-versus-host-like disease.

Authors
Type
Published Article
Journal
Journal of the American Academy of Dermatology
Publisher
Elsevier
Volume
57
Issue
4
Pages
683–683
Source
maverakislab-ucdavis dermatology-ucdavis
License
Unknown

Abstract

Graft-versus-host disease (GVHD) is a T cell-mediated disease seen most commonly after hematopoietic stem cell transplantation. Rarely, a GVHD-like disease can be seen in patients with malignant thymoma. We describe a 50-year-old man with malignant thymoma who developed skin, liver, and intestinal manifestations similar to that seen in GVHD. We also review other reported cases of GVHD-like manifestations in the setting of thymoma and propose "thymoma-associated multiorgan autoimmunity" as a name for this novel disease. Specifically, thymoma-associated multiorgan autoimmunity is defined as a disease of the liver, intestine, or skin, which on histopathology resembles GVHD but is seen in the setting of malignant thymoma and not after hematopoietic stem cell transplantation.

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