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Thymocytes are activated by toluene inhalation through the transcription factors NF-κB, STAT5 and NF-AT.

Authors
  • Liu, Jiqin
  • Yoshida, Yasuhiro
  • Kunugita, Naoki
  • Noguchi, Junko
  • Sugiura, Tsutomu
  • Ding, Ning
  • Arashidani, Keiichi
  • Fujimaki, Hidekazu
  • Yamashita, Uki
Type
Published Article
Journal
Journal of Applied Toxicology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Oct 01, 2010
Volume
30
Issue
7
Pages
656–660
Identifiers
DOI: 10.1002/jat.1536
PMID: 20981857
Source
Medline
License
Unknown

Abstract

Toluene has been extensively examined for effects on the central nervous system. To investigate the influence of low-level inhalation of toluene on the naive immune cells, male C3H/HeN mice were exposed to filtered air (control) and 50 ppm of toluene for 3 weeks. Low-level exposure resulted in (1) increased proliferation of thymocytes, (2) IL-2 production induced in thymocytes and (3) activation of the transcription factors NF-κB, STAT5 and NF-AT in thymocytes. These results suggest that thymocytes are sensitive cells and T cell activators are candidates for biomarkers for low-level exposure to toluene on naive immune cells.

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