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Thrombosis and Haemostasis challenges in COVID-19 – Therapeutic perspectives of heparin and tissue-type plasminogen activator and potential toxicological reactions-a mini review

Authors
  • Mazilu, Laura1
  • Katsiki, Niki2
  • Nikolouzakis, Taxiarchis Konstantinos3
  • Aslanidis, Minas I.4
  • Lazopoulos, George5
  • Kouretas, Dimitrios3
  • Tsatsakis, Aristidis6
  • Suceveanu, Andra-Iulia7
  • Stoian, Anca-Pantea8
  • Parepa, Irinel-Raluca9
  • Voinea, Felix10
  • Suceveanu, Adrian Paul11
  • Arsene, Andreea Letiția12
  • Velescu, Bruno Ștefan12
  • Vesa, Cosmin13
  • Nitipir, Cornelia14
  • 1 Oncology Department, Clinical Emergency Hospital, Faculty of Medicine, “Ovidius” University, Constanța, Romania
  • 2 First Department of Internal Medicine, Diabetes Center, Division of Endocrinology and Metabolism, AHEPA University Hospital, Thessaloniki, Greece
  • 3 Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, Greece
  • 4 School of Medicine, European University, Cyprus
  • 5 Department of Cardiothoracic Surgery, University General Hospital of Heraklion, Medical School, University of Crete, Greece
  • 6 Department of Biochemistry and Biotechnology, University of Thessaly, Larisa, 41500, Greece
  • 7 Gastroenterology Department, Clinical Emergency Hospital, Faculty of Medicine, “Ovidius” University, Constanța, Romania
  • 8 Department of Diabetes, Nutrition and Metabolic Diseases, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
  • 9 Cardiology Department, Clinical Emergency Hospital, Faculty of Medicine, “Ovidius” University, Constanța, Romania
  • 10 Urology Department, Clinical Emergency Hospital, Faculty of Medicine, “Ovidius” University, Constanța, Romania
  • 11 Internal Medicine Department, Clinical Emergency Hospital, Faculty of Medicine, “Ovidius” University, Constanța, Romania
  • 12 Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
  • 13 Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania
  • 14 Oncology Department, Elias Emergency Hospital, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Type
Published Article
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Publication Date
Jan 06, 2021
Volume
148
Pages
111974–111974
Identifiers
DOI: 10.1016/j.fct.2021.111974
PMID: 33421462
PMCID: PMC7837001
Source
PubMed Central
Keywords
License
Unknown

Abstract

• Anticoagulant therapy is essential in decreasing fibrin deposition and microthrombus formation in the ARDS and in the treatment of pro-thrombotic complications. • Administration of tPA in ARDS patients could provide anti-inflammatory effects. • Heparin and tPA may be useful in these patients minimizing the risk for ARDS complications and/or reducing the pressure on the ventilator support in the Intensive Care Unit

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