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Thromboprophylaxis and obstetric management of the antiphospholipid syndrome.

Authors
  • Espinosa, Gerard
  • Cervera, Ricard
Type
Published Article
Journal
Expert Opinion on Pharmacotherapy
Publisher
Informa UK (Taylor & Francis)
Publication Date
Mar 01, 2009
Volume
10
Issue
4
Pages
601–614
Identifiers
DOI: 10.1517/14656560902772302
PMID: 19284363
Source
Medline
License
Unknown

Abstract

There is consensus in treating patients with antiphospholipid syndrome (APS) and first venous thrombosis with oral anticoagulation to a target international normalized ratio of 2.0 - 3.0. A recent systematic review recommended a target international normalized ratio > 3.0 in the group of patients with APS and arterial thrombosis. The approach for women with obstetric manifestations of APS is based on the use of aspirin plus heparin. In addition, we summarize the evidence-based information about management of catastrophic APS and some difficult cases, such as 'seronegative' APS, patients who do not display formal classification criteria for APS, and recurrent thrombotic events despite optimal anticoagulation.

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