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Thrombocytopenia associated with linezolid therapy.

Authors
  • Attassi, Kinan
  • Hershberger, Ellie
  • Alam, Rabiul
  • Zervos, Marcus J
Type
Published Article
Journal
Clinical Infectious Diseases
Publisher
Oxford University Press
Publication Date
Mar 01, 2002
Volume
34
Issue
5
Pages
695–698
Identifiers
PMID: 11803505
Source
Medline
License
Unknown

Abstract

We evaluated the incidence and clinical characteristics of linezolid-induced thrombocytopenia in 19 patients who were treated with linezolid. Overall, thrombocytopenia (platelet count, <100,000 platelets/mm(3)) was observed in 32% of patients who received linezolid for >10 days; gastrointestinal bleeding was observed in 1 patient and 4 patients required platelet transfusions. These data suggest that even patients who are not considered to be at risk for development of thrombocytopenia should be monitored closely if linezolid therapy is continued for >10 days.

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