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Thrombin and platelet activation.

Authors
Type
Published Article
Journal
Chest
Publication Date
Volume
124
Issue
3 Suppl
Identifiers
PMID: 12970120
Source
Medline
License
Unknown

Abstract

The accumulation of thrombin at sites of vascular injury provides one of the chief means for recruiting platelets into a growing hemostatic plug. Studies completed over the past 10 years show that platelet responses to thrombin are mediated by a subset of G protein-coupled receptors known as protease-activated receptors. These receptors are activated on cleavage by thrombin, initiating the intracellular signaling events needed to transform mobile, nonadhesive platelets into cells that can participate in the growth of an immobile hemostatic plug. How this is accomplished is the subject of this review.

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