Affordable Access

Access to the full text

Thrombin Generation in Vitreous and Subretinal Fluid of Patients with Retinal Detachment

Authors
  • Mulder, Verena C.
  • Bastiaans, Jeroen
  • van Leuven, Cornelis J.M.
  • van Meurs, Jan C.
  • Kluft, Cornelis
Type
Published Article
Journal
Ophthalmologica
Publisher
S. Karger AG
Publication Date
Apr 04, 2018
Volume
240
Issue
1
Pages
23–28
Identifiers
DOI: 10.1159/000487757
PMID: 29617690
Source
Karger
Keywords
License
Green
External links

Abstract

Purpose: To measure prothrombin fragments (F1+2) and thrombin-antithrombin complex (TAT) in vitreous and subretinal fluid (SRF) of rhegmatogenous retinal detachment (RRD) patients and to validate and further specify our earlier finding of increased thrombin activity in patients with proliferative vitreoretinopathy (PVR). Methods: F1+2 and TAT were measured in 31 vitreous and 16 SRF samples using the Enzygnost® immunoassays. Results: We found significant levels of F1+2 and TAT in the vitreous of all patients with RRD compared to patients with macular hole or macular pucker. However, there was no significant difference between patients who would develop PVR in the future, had established PVR, and patients with uncomplicated RRD both in vitreous concentrations of F1+2 (Kruskal-Wallis p = 0.963) and TAT (p = 0.516). Conclusion: The analysis of F1+2 and TAT confirmed significant thrombin generation in both vitreous and SRF of patients with RRD. An imbalance between the thrombin regulation mechanisms TAT and α2-macroglobulin possibly explains the difference from our previous findings.

Report this publication

Statistics

Seen <100 times