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Thrombelastographic patterns during cryotherapy for recurrent hepatocellular carcinoma.

Authors
  • Ng, K F
Type
Published Article
Journal
Hepato-gastroenterology
Publication Date
Jan 01, 1999
Volume
46
Issue
25
Pages
448–452
Identifiers
PMID: 10228839
Source
Medline
License
Unknown

Abstract

A cirrhotic patient with recurrent hepatocellular carcinoma and thrombocytopenia undergoing cryotherapy showed: 1) transient hyperfibrinolysis shortly after platelet transfusion, and 2) evidence of activation of coagulation after freezing and thawing of tumor as measured on the thrombelastography. No anti-fibrinolytic treatment was required for the hyperfibrinolysis which subsided spontaneously in this patient. This case report highlights that: 1) in patients with chronic liver disease, platelet transfusion might potentially worsen rather than improve the hemostatic function by activation of fibrinolysis, and 2) activation of coagulation may underlie the perioperative coagulation changes seen in cryotherapy.

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