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Three-dimensional organization and dynamics of the genome

Authors
  • Szalaj, Przemyslaw1, 2, 3
  • Plewczynski, Dariusz1, 3, 4
  • 1 Medical University of Bialystok, Centre for Innovative Research, Białystok, Poland , Białystok (Poland)
  • 2 Hasselt University, I-BioStat, Hasselt, Belgium , Hasselt (Belgium)
  • 3 University of Warsaw, Centre of New Technologies, Warsaw, Poland , Warsaw (Poland)
  • 4 Warsaw University of Technology, Faculty of Mathematics and Information Science, Warsaw, Poland , Warsaw (Poland)
Type
Published Article
Journal
Cell Biology and Toxicology
Publisher
Springer Netherlands
Publication Date
Mar 22, 2018
Volume
34
Issue
5
Pages
381–404
Identifiers
DOI: 10.1007/s10565-018-9428-y
Source
Springer Nature
Keywords
License
Green

Abstract

Genome is a complex hierarchical structure, and its spatial organization plays an important role in its function. Chromatin loops and topological domains form the basic structural units of this multiscale organization and are essential to orchestrate complex regulatory networks and transcription mechanisms. They also form higher-order structures such as chromosomal compartments and chromosome territories. Each level of this intrinsic architecture is governed by principles and mechanisms that we only start to understand. In this review, we summarize the current view of the genome architecture on the scales ranging from chromatin loops to the whole genome. We describe cell-to-cell variability, links between genome reorganization and various genomic processes, such as chromosome X inactivation and cell differentiation, and the interplay between different experimental techniques.

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