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Three-Dimensional Deep Noninvasive Radiomics for the Prediction of Disease Control in Patients With Metastatic Urothelial Carcinoma treated With Immunotherapy.

Authors
  • Rundo, Francesco1
  • Bersanelli, Melissa2
  • Urzia, Valeria3
  • Friedlaender, Alex4
  • Cantale, Ornella5
  • Calcara, Giacomo6
  • Addeo, Alfredo4
  • Banna, Giuseppe Luigi7
  • 1 STMicroelectronics ADG Central R&D, Catania, Italy. , (Italy)
  • 2 Medical Oncology Unit, Medicine and Surgery Department, University of Parma, Parma, Italy. Electronic address: [email protected] , (Italy)
  • 3 PS-MCAU, Umberto I Hospital, Siracusa, Italy. , (Italy)
  • 4 Oncology Department, Geneva University Hospital, Geneva, Switzerland. , (Switzerland)
  • 5 Department of Experimental Oncology, Istituto Oncologico del Mediterraneo, Viagrande, Italy. , (Italy)
  • 6 Division of Medical Oncology and Department of Radiology, Cannizzaro Hospital, Catania, Italy. , (Italy)
  • 7 Division of Medical Oncology and Department of Radiology, Cannizzaro Hospital, Catania, Italy; Department of Oncology, Portsmouth Hospitals NHS Trust, Portsmouth, United Kingdom. , (United Kingdom)
Type
Published Article
Journal
Clinical Genitourinary Cancer
Publisher
Elsevier
Publication Date
Oct 01, 2021
Volume
19
Issue
5
Pages
396–404
Identifiers
DOI: 10.1016/j.clgc.2021.03.012
PMID: 33849811
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Immunotherapy is effective in a small percentage of patients with cancer and no reliable predictive biomarkers are currently available. Artificial Intelligence algorithms may automatically quantify radiologic characteristics associated with disease response to medical treatments. We investigated an innovative approach based on a 3-dimensional (3D) deep radiomics pipeline to classify visual features of chest-abdomen computed tomography (CT) scans with the aim of distinguishing disease control from progressive disease to immune checkpoint inhibitors (ICIs). Forty-two consecutive patients with metastatic urothelial cancer had progressed on first-line platinum-based chemotherapy and had baseline CT scans at immunotherapy initiation. The 3D-pipeline included self-learned visual features and a deep self-attention mechanism. According to the outcome to the ICIs, a 3D deep classifier semiautomatically categorized the most discriminative region of interest on the CT scans. With a median follow-up of 13.3 months (95% CI, 11.1-15.6), the median overall survival was 8.5 months (95% CI, 3.1-13.8). According to disease response to immunotherapy, the median overall survival was 3.6 months (95% CI, 2.0-5.2) for patients with progressive disease; it was not yet reached for those with disease control. The predictive accuracy of the 3D-pipeline was 82.5% (sensitivity 96%; specificity, 60%). The addition of baseline clinical factors increased the accuracy to 92.5% by improving specificity to 87%; the accuracy of other architectures ranged from 72.5% to 90%. Artificial Intelligence by 3D deep radiomics is a potential noninvasive biomarker for the prediction of disease control to ICIs in metastatic urothelial cancer and deserves validation in larger series. Copyright © 2021 Elsevier Inc. All rights reserved.

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