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Three-dimensional decellularized tumor extracellular matrices with different stiffness as bioengineered tumor scaffolds

Authors
  • Lv, Yonggang1, 2
  • Wang, Hongjun1, 2
  • Li, Gui1, 2
  • Zhao, Boyuan1, 2
  • 1 Mechanobiology and Regenerative Medicine Laboratory, Bioengineering College, Chongqing University, Chongqing, 400044, PR China
  • 2 Key Laboratory of Biorheological Science and Technology, Chongqing University, Ministry of Education, Bioengineering College, Chongqing University, Chongqing, 400044, PR China
Type
Published Article
Journal
Bioactive Materials
Publisher
KeAi Publishing
Publication Date
Feb 15, 2021
Volume
6
Issue
9
Pages
2767–2782
Identifiers
DOI: 10.1016/j.bioactmat.2021.02.004
PMID: 33665508
PMCID: PMC7897907
Source
PubMed Central
Keywords
License
Unknown

Abstract

• Novel 3D bioengineered tumor scaffolds with different stiffness were developed. • Cells with different LOX expression levels were used to generate tumor tissue. • DECM scaffold has good cytocompatibility. • DECM with high stiffness promotes the resistance of MDA-MB-231 cells to cisplatin. • DECM with high stiffness increases the expression of Bcl-2 and ABCB1.

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