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Three-dimensional bioprinting of gelatin methacryloyl (GelMA)

Authors
  • Ying, Guoliang1, 2
  • Jiang, Nan3
  • Yu, Cunjiang4
  • Zhang, Yu Shrike1
  • 1 Harvard Medical School, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Cambridge, MA, 02139, USA , Cambridge (United States)
  • 2 Wuhan Institute of Technology, School of Materials Science and Engineering, Wuhan, 430205, People’s Republic of China , Wuhan (China)
  • 3 Harvard University, School of Engineering and Applied Sciences, Cambridge, MA, 02139, USA , Cambridge (United States)
  • 4 University of Houston, Departments of Mechanical Engineering, Electrical and Computer Engineering, Biomedical Engineering, Materials Science and Engineering Program, The Texas Center for Superconductivity, Houston, TX, 77204, USA , Houston (United States)
Type
Published Article
Journal
Bio-Design and Manufacturing
Publisher
Springer Singapore
Publication Date
Nov 16, 2018
Volume
1
Issue
4
Pages
215–224
Identifiers
DOI: 10.1007/s42242-018-0028-8
Source
Springer Nature
Keywords
License
Yellow

Abstract

The three-dimensional (3D) bioprinting technology has progressed tremendously over the past decade. By controlling the size, shape, and architecture of the bioprinted constructs, 3D bioprinting allows for the fabrication of tissue/organ-like constructs with strong structural–functional similarity with their in vivo counterparts at high fidelity. The bioink, a blend of biomaterials and living cells possessing both high biocompatibility and printability, is a critical component of bioprinting. In particular, gelatin methacryloyl (GelMA) has shown its potential as a viable bioink material due to its suitable biocompatibility and readily tunable physicochemical properties. Current GelMA-based bioinks and relevant bioprinting strategies for GelMA bioprinting are briefly reviewed.

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